Certolizumab Pegol: A New Therapeutic Approach for Acrodermatitis Continua of Hallopeau-Reference-Cited by-同舟云学术

Certolizumab Pegol: A New Therapeutic Approach for Acrodermatitis Continua of Hallopeau

Published:2021-09-17 Issue: Volume: Page:1-4
ISSN:2296-9195
Container-title:Skin Appendage Disorders
language:en
Short-container-title:Skin Appendage Disord

Author:

Rizzetto Giulio,Diotallevi Federico,Molinelli Elisa,Radi Giulia,Offidani Anna Maria

Abstract

Introduction: Acrodermatitis continua of Hallopeau (ACH) is a rare, chronic, and recurrent form of pustular psoriasis (PP) localized to one or more digits. Due to the rarity of ACH, no clear treatment guidelines are currently available, making the therapeutic approach more complex. Case Presentation: We report the first case of a young woman with ACH who was successfully treated with certolizumab pegol (CZP). Discussion/Conclusion: PP and ACH are difficult to treat, and biologics may be an option more manageable than cyclosporine. CZP is the safest biologic therapy during pregnancy, so there is low risk in prescribing it in women with childbearing potential. However, continuing biological therapy during pregnancy always involves an assessment of the clinical benefits, which must outweigh the risks.

Publisher

S. Karger AG

Subject

Dermatology

Reference7 articles.

1. Bachelez H. Pustular psoriasis and related pustular skin diseases. Br J Dermatol. 2018;178(3):614–8.

2. Sehgal VN, Verma P, Sharma S, Srivastava G, Aggarwal AK, Rasool F, et al. Acrodermatitis continua of hallopeau: evolution of treatment options. Int J Dermatol. 2011;50(10):1195–211.

3. Korman AM, Rzepka PV, Sopkovich JA. Acrodermatitis continua of hallopeau. JAMA Dermatol. 2018;154(11):1346.

4. Maliyar K, Crowley EL, Rodriguez-Bolanos F, OʼToole A, Gooderham MJ. The use of biologic therapy in the treatment of acrodermatitis continua of hallopeau: a review. J Cutan Med Surg. 2019 Jul/Aug;23(4):428–35.

5. Mizutani Y, Mizutani YH, Matsuyama K, Kawamura M, Fujii A, Shu E, et al. Generalized pustular psoriasis in pregnancy, successfully treated with certolizumab pegol. J Dermatol. 2020 Jul;47(7):e262–3.