Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19
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Published:2021
Issue:4
Volume:182
Page:324-338
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ISSN:1018-2438
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Container-title:International Archives of Allergy and Immunology
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language:en
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Short-container-title:Int Arch Allergy Immunol
Author:
Bousquet Jean, Czarlewski Wienczyslawa, Zuberbier TorstenORCID, Mullol Joaquim, Blain Hubert, Cristol Jean-Paul, De La Torre Rafael, Pizarro Lozano Nieves, Le Moing Vincent, Bedbrook Anna, Agache Ioana, Akdis Cezmi A., Canonica G. Walter, Cruz Alvaro A., Fiocchi Alessandro, Fonseca Joao A., Fonseca Susana, Gemicioğlu Bilun, Haahtela Tari, Iaccarino Guido, Ivancevich Juan Carlos, Jutel Marek, Klimek Ludger, Kraxner Helga, Kuna Piotr, Larenas-Linnemann Désirée E., Martineau Adrian, Melén Erik, Okamoto Yoshitaka, Papadopoulos Nikolaos G., Pfaar OliverORCID, Regateiro Frederico S., Reynes Jacques, Rolland Yves, Rouadi Philip W., Samolinski Boleslaw, Sheikh Aziz, Toppila-Salmi Sanna, Valiulis Arunas, Choi Hak-Jong, Kim Hyun Ju, Anto Josep M.
Abstract
In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.
Subject
Immunology,General Medicine,Immunology and Allergy
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