Structure-Function Analysis of MP-3 Microperimetry versus Octopus Perimetry in Central Glaucomatous Visual Field Defects

Abstract

<b><i>Introduction:</i></b> The aim of this study was to compare the structure-function relationship with microperimetry and Octopus perimetry in primary open-angle glaucoma (POAG) patients with central visual field (VF) defects. <b><i>Methods:</i></b> Forty eyes of 24 patients with POAG were enrolled. Circumpapillary retinal nerve fiber layer (cpRNFL) analysis measured by spectral-domain optical coherence tomography (SD-OCT) of the superotemporal, temporal, and inferotemporal optic-nerve head sectors were related to corresponding microperimetric and Octopus VF clusters using the G2 grid-pattern with dynamic strategy, respectively. The structure-function relationships of both devices were assessed via a segmented regression, as well as linear regression across overall SD-OCT cpRNFL values and outside normative (&#x3c;1%) SD-OCT cpRNFL values. <b><i>Results:</i></b> Linear and segmented regression fits were similar with both devices. Across overall cpRNFL sectorial values, structure-function relations for the superotemporal, temporal, and inferotemporal sectors were <i>R</i>² = 0.176 (<i>p</i> = &#x3c;0.001), <i>R</i>² = 0.008 (<i>p</i> = 0.069), and <i>R</i>² = 0.294 (<i>p</i> = &#x3c;0.001) for microperimetry and <i>R</i>² = 0.189 (<i>p</i> = &#x3c;0.001), <i>R</i>² = 0.020 (<i>p</i> = 0.002), and <i>R</i>² = 0.326 (<i>p</i> = &#x3c;0.001) for Octopus perimetry. For corresponding values outside normative limits (&#x3c;1%), the relationships were <i>R</i>² = 0.113 (<i>p</i> = &#x3c;0.001), <i>R</i>² = 0.001 (<i>p</i> = 0.836), and <i>R</i>² = 0.420 (<i>p</i> = &#x3c;0.001) for microperimetry and <i>R</i>² = 0.192 (<i>p</i> = &#x3c;0.001), <i>R</i>² = 0.002, (<i>p</i> = 0.336), and <i>R</i>² = 0.366 (<i>p</i> = &#x3c;0.001) for Octopus perimetry. <b><i>Discussion/Conclusion:</i></b> Structure-function analysis was similar for both devices. Fundus-tracking should be further evaluated in a longitudinal setting in patients affected by glaucoma.