Vismodegib-Induced Alopecia: Trichoscopic and Confocal Microscopy Evaluation-Reference-Cited by-同舟云学术

Vismodegib-Induced Alopecia: Trichoscopic and Confocal Microscopy Evaluation

Published:2020 Issue:6 Volume:6 Page:384-388
ISSN:2296-9195
Container-title:Skin Appendage Disorders
language:en
Short-container-title:Skin Appendage Disord

Author:

Cantelli Mariateresa,Cappello Milena,Vastarella Maria,Patrì Angela,Scalvenzi Massimiliano,Fabbrocini Gabriella

Abstract

Introduction: Vismodegib is the first-in-class inhibitor of the sonic hedgehog pathway useful in the treatment of locally advanced or metastatic basal cell carcinoma (BCC) that is not amenable to surgery and radiation therapy. Common adverse events of vismodegib, probably mechanism related, include alopecia (58%) as a reversible side effect. Case Presentation: We report 2 cases of patients receiving vismodegib for the treatment of locally advanced BCCs that developed alopecia during treatment and describe clinical, dermoscopic, and reflectance confocal microscopy (RCM) features of this adverse event. Conclusion: Alopecia is one of the most distressing adverse events leading to vismodegib discontinuations. To our knowledge, these are the first descriptions of RCM dermoscopy in vismodegib-induced alopecia. Trichoscopy and confocal microscopy are essential to monitoring vismodegib hair loss and the response to the treatment.

Publisher

S. Karger AG

Subject

Dermatology

Reference8 articles.

1. Gould SE, Low JA, Marsters JC, Robarge K, Rubin LL, de Sauvage FJ, et al. Discovery and preclinical development of vismodegib. Expert Opin Drug Discov. 2014 Aug;9(8):969–84.

2. Chang AL, Solomon JA, Hainsworth JD, Goldberg L, McKenna E, Day BM, et al. Expanded access study of patients with advanced basal cell carcinoma treated with the hedgehog pathway inhibitor, vismodegib. J Am Acad Dermatol. 2014 Jan;70(1):60–9.

3. Franceschini C, Garelli V, Persechino F, Sperduti I, Caro G, Rossi A, et al. Dermoscopy and confocal microscopy for different chemotherapy-induced alopecia (CIA) phases characterization: preliminary study. Skin Res Technol. 2020;26(2):269–76.

4. Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8(10):743–54.

5. Wang LC, Liu ZY, Gambardella L, Delacour A, Shapiro R, Yang J, et al. Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol. 2000;114(5):901–8.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cutaneous adverse reactions resulting from targeted cancer therapies: histopathologic and clinical findings;Human Pathology;2023-10

2. Medication-induced hair loss: An update;Journal of the American Academy of Dermatology;2023-08