Author:
Motamedi Melika,Xiao Maggie Z.X.,Deschenes Jean,Hardin Jori,Sterrett Russell,Street Lesley,Taparia Minakshi,Mahe Etienne,Ferrara Giovanni,Barrie James R.,Gniadecki Robert
Abstract
<b><i>Background:</i></b> Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate. <b><i>Objective:</i></b> The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented. <b><i>Methods:</i></b> We performed a systematic review of 116 GMF cases previously described in the literature. <b><i>Results:</i></b> In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months. <b><i>Conclusion:</i></b> GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.