Impact of COVID-19 in Pediatric Patients and Young Adults with Inflammatory Bowel Disease

Abstract

<b><i>Introduction:</i></b> Acute COVID-19 in pediatric and young adult patients tends to be milder in severity compared to adult infection. Recent studies seem to show that inflammatory bowel disease (IBD) patients are at no greater risk than the general population. We aim to describe our experience in the follow-up of pediatric and young adult patients with IBD followed in our center and determine possible risk factors of said population for severe COVID-19. <b><i>Methods:</i></b> We performed a retrospective study of all patients aged under 25 years followed for IBD at the Unit of Pediatric Gastroenterology in a tertiary center between December 2019 and April 2021 evaluating the incidence of COVID-19 and characterization of positive cases. <b><i>Results:</i></b> Of the 268 participants, 24 had COVID-19: the mean age was 19 years old and gender had an equal distribution; 75% (<i>n</i> = 18) had Crohn’s disease, whereas only 25% (<i>n</i> = 6) had ulcerative colitis. Most patients were in clinical remission (<i>n</i> = 21). The majority of patients were under treatment with a tumor necrosis factor (TNF) antagonist (58%, <i>n</i> = 14), mainly infliximab, and most had no comorbidities other than IBD (83%). Regarding COVID-19, 17% of the patients were asymptomatic while the rest had only mild symptoms. There were no reported gastrointestinal complaints, no complications nor hospitalizations. Most patients did not require interruption of their IBD treatment. <b><i>Conclusions:</i></b> Our data suggest that pediatric and young adult IBD patients have a low risk for complications and hospitalization, regardless of IBD treatment. We believe that this experience is encouraging and allows for safe counseling regarding treatment options and school attendance in pediatric and young adult IBD patients.