Vascular Endothelial Growth Factor as a Predictive and Prognostic Biomarker for Multiple Sclerosis

Abstract

<b><i>Background:</i></b> Growing bodies of evidence suggest that angiogenesis plays a crucial role in the development and progression of multiple sclerosis (MS). Vascular endothelial growth factor (VEGF) is one of the key factors involved in angiogenesis. Because of this importance, we investigated the serum levels of VEGF in MS patients according to their clinical phase and subtype of MS in this study. <b><i>Material and Methods:</i></b> This case-control study was done on 47 definite MS patients with the first clinical attack and 47 randomly selected individuals without any underlying inflammatory and autoimmune disease as the control group. The total serum VEGF level was measured from the subject’s peripheral blood sample by ELISA during the first and second attacks of MS and 6 months after the first attack in the remission phase as well as the control group. In addition, the correlation between these variables and the influence of gender, age, and duration of the remission phase on such associations was evaluated by using the independent <i>t</i> test and Pearson’s correlation coefficient. <b><i>Results:</i></b> There was an increase in the serum level of VEGF in all phases of MS compared with non-MS individuals (<i>p</i> value &#x3c;0.0001) and a significant correlation between the serum level of VEGF and the interval between first and second attacks (<i>r</i> = −720, <i>p</i> &#x3c; 0.0001). A higher serum level of VEGF in the first attack leads to higher VEGF levels in the second and sixth mount of remission phases. <b><i>Conclusion:</i></b> Rise in the serum VEGF level may be involved in MS’s relapsing phases and a shorter remission phase. Therefore, it could be used as a prognostic and predictive biomarker for MS disease.