Experimental study: effects of folic acid, vitamin C, and vitamin E on fat graft survival

Abstract

Aim: This study explores the potential of folic acid (vitamin B9), ascorbic acid (vitamin C), and α-tocopherol (vitamin E) to enhance fat graft survival. Material and Method: The dorsal regions of the Sprague-Dawley rats (n=10) were divided into four quadrants as inguinal fat donor recipient sites. After incubation, fat grafts were placed into sites (0.9% NaCl-left cranial, vitamin B9-right cranial, vitamin C-left caudal, and vitamin E-right caudal). At the end of the third month, fat grafts were harvested. Fat grafts were evaluated immunohistochemically with perilipin to reveal viability. Results: Folic acid, vitamin C, and vitamin E were shown improved fat graft survival rate with perilipin (p