Dose Response of Total Saponins Isolated from the Stem Bark of Dialium Guineense-Reference-Cited by-同舟云学术

Dose Response of Total Saponins Isolated from the Stem Bark of Dialium Guineense

Published:2022-03-21 Issue:4 Volume:1 Page:1-6
ISSN:2638-4469
Container-title:Journal of Advances in Plant Biology
language:en
Short-container-title:JAPB

Author:

Abu O.D.,¹,Onoagbe I.O.,¹,Ojo I.,²

Affiliation:

1. Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.

2. Department of Chemistry, College of Arts and Sciences, University of Kentucky, Lexington, USA.

Abstract

The safety of plant-derived bioactive compounds has become a global concern. The present study investigated the dose response of total saponins isolated from the stem bark of Dialiumguineense. Adultmale Wistar rats (n = 15) weighing 170 – 190 g (mean weight = 180 ± 10 g) were randomly assigned to three groups (5 rats per group). The rats received varied doses of total saponins isolated from the stem bark of the medicinal plant (50 - 150 mg/kg body weight, bwt) orally for a period of 9 days. The concentration of fasting blood glucose (FBG) was used as the therapeutic index.The results of the analysis revealed that total saponins isolated from the stem bark of D. guineense significantly reduced the Fasting Blood Glucose (FBG) levels of normal Wistar rats (p < 0.05). The graded and quantal dose-response curves showed that150 mg/kg bwt was effective in reducing the blood glucose of rats (produced the best hypoglycemic effect). The study concluded that total saponins isolated from the stem bark of D. guineense possesses hypoglycemic effect at a relatively good dose.

Publisher

Open Access Pub

Reference15 articles.

1. 1.Handa S S, S P Khanuja, Longo G, Rakesh D D. (2008) Extraction technologies for medicinal and aromatic plants. International center for science and high technology. , Trieste, Italy 1, 266.

2. 2.Sandoval M, Okuhama N N, X J Zhang, L A Condezo, Lao J. (2002) Anti-inflammation and antioxidant activities of cat’s claw (Uncaria tomentos and Uncaria guianensis) are independent of their alkaloid content. , Phytomedicine 9, 325-337.

3. 3.O D Abu, K E Imafidon, M E Iribhogbe. (2015) Biochemical effect of aqueous leaf extract of Icacina trichanta Oliv. on urea, creatinine and kidney oxidative status in CCl4-induced Wistar rats. , Nigerian Journal of Life Sciences 5(1), 85-89.

4. 4.O D Abu, I O Onoagbe. (2021) Acute toxicity of aqueous and ethanol extracts ofDialiumguineensestem bark.Journal of. 10(2), 427-432.

5. 5.O D Abu, E F Adeogun, S O Ebhohon. (2019) Oral LD50 of total saponins and tannins isolated from Dialiumguineensestem bark.European. , Journal of Experimental Biology.9 2, 11-13.