Affiliation:
1. Department of Intensive Care Unit, People’s Hospital of Qiandongnan Miao and Dong Autonomous Prefecture, Kaili, Guizhou 556000, China
Abstract
Alveolar-arterial oxygen pressure difference (P(Aa)O2) can reflect pulmonary ability to exchange oxygen; it shows good correlation with the oxygenation index (OI), which is important in diagnosing acute respiratory distress syndrome (ARDS). This study explored the ability of P(Aa)O2 in diagnosing ARDS in pneumonia patients.
Methods
We selected patients with community-acquired pneumonia and sepsis in the intensive care unit (ICU) of the People’s Hospital of Qiandongnan Miao and Dong Autonomous Prefecture; we measured P(Aa)O2 and the OI under anoxic conditions upon their admittance to the ICU. We divided the patients into ARDS and non-ARDS groups. We compared the differences in P(Aa)O2 and OI; we analyzed the correlation between P(Aa)O2 and ARDS. To assess the diagnostic ability of P(Aa)O2 for ARDS, we drew the receiver operating characteristic (ROC) curve.
Result
We found that P(Aa)O2 in the ARDS group was greater than in the non-ARDS group (t = 8.875, P <0.001); the OI in the ARDS group was smaller than in the non-ARDS group (t = –6.956, P <0.001). There was a positive correlation between P(Aa)O2 and ARDS (r = 0.718, P <0.001). The area under the ROC curve for P(Aa)O2 in the diagnosis of ARDS was 0.931 (0.873–0.988); the cutoff value was 214.70 mmHg, the sensitivity was 89.50%, and the specificity was 85.00%.
Conclusion
We conclude that P(Aa)O2 is a good reference index in diagnosing ARDS
Reference28 articles.
1. 1.Zhao J J, Zhou X M, Yao L. (2018) Analysis of the risk factors of acute respiratory distress syndrome in patients with severe pneumonia in intensive care unit. , Chinese Journal of Respiratory and Critical Care Medicine 17(06), 561-564.
2. 2.Schmickl C N, Biehl M, Wilson G A, Gajic O. (2015) Comparison of hospital bortality and long-term survival in patients with acute lung injury/ARDS vs cardiogenic pulmonary edema.Chest. 147(3), 618-625.
3. 3.Sweeney R M, Mcauly D F. (2016) Acute respiratory distress syndrome. , Lancet 388(10058), 2416-2430.
4. 4.Chinh L Q, Manabe T, Son D N, Chi N V, Nguyen D A. (2019) Clinical epidemiology and mortality on patients with acute respiratory distress syndrome (ARDS). in Vietnam. PLoS ONE 14(8), 0221114.
5. 5.Wang Y, Huang D, Liang Z A. (2020) Procalcitonin-to-albumin ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective cohort study. , Chinese Journal of Respiratory and Critical Care Medicine 19(03), 38-43.