The role of Helicobacter pylori in complex human comorbidity

Abstract

One of the main features of modern medicine is the fact that most somatic diseases lose their mononosological character, acquiring the status of comorbidity. Comorbidity has become a separate research area in various specialties of medicine and is currently being formalized into a system of knowledge about the patterns of combination of diseases. With regard to infectious pathology, the term "comorbidity" is rarely mentioned. In the conventional sense, comorbidity is understood as a combination of two or more diseases in a patient at the same time.In our opinion, the term "comorbidity" can be applied from the standpoint of the simultaneous combination of somatic and infectious diseases, but with a certain addition. In particular, it can be used in relation to somatic pathology with simultaneous combination with both monoinfection and polyetiologic. This is "complex comorbidity", which should be understood as "a complex pathological condition of a person, characterized by a simultaneous or sequential combination of psychosomatic and infectious pathology. It can take place when one or more infectious diseases are combined in combination with psychosomatic nosologies consisting of one or more units. "Over the past decade, a significant number of works have appeared on the role of H. pylori in the etiology and pathogenesis of a large number of somatic diseases. H. pylori plays in the development of many diseases - both associated with the stomach and determining the damage to other organs and systems. The clinical significance of this infection is determined by its leading role in the formation of chronic gastritis, gastric ulcer and duodenal ulcer, MALT lymphoma, and gastric adenocarcinoma. There is good evidence for the association of H. pylori infection with idiopathic iron deficiency anemia and idiopathic thrombocytopenic purpura. The clinical aspects of H. pylori infection are heterogeneous and include a wide range of pathologies, the evidence base for which at both the pathogenetic and clinical levels continues to expand.