Results of implementation of viral hepatitis B elimination program in the North-West Russia-Reference-Cited by-同舟云学术

Results of implementation of viral hepatitis B elimination program in the North-West Russia

Published:2021-09-01 Issue:5 Volume:11 Page:875-886
ISSN:2313-7398
Container-title:Russian Journal of Infection and Immunity
language:
Short-container-title:iimm

Author:

Lyalina L. V.¹^ORCID,Esaulenko E. V.²^ORCID,Khorkova E. V.³^ORCID,Novak K. E.⁴^ORCID,Ostankova Y. V.⁵^ORCID,Serikova E. N.⁵^ORCID,Vasilyev D. V.⁶,Gorziy E. S.¹^ORCID,Butskaya M. J.²,Kritskaya I. V.⁷^ORCID,Buts L. V.⁸^ORCID,Grebenkina E. V.⁹,Baydakova E. V.¹⁰,Smirnova N. A.¹¹,Krasnopyorova M. A.¹²,Koltsov N. S.¹³,Kotovich L. M.¹⁴,Kalinina E. L.¹⁵,Galimov R. R.¹⁶,Kirkhar N. V.¹⁷,Cherepanova E. A.¹⁸,Totolian Areg A.⁵^ORCID

Affiliation:

1. St. Petersburg Pasteur Institute; North-Western State Medical University named after I.I. Mechnikov

2. St. Petersburg Pasteur Institute; St. Petersburg State Pediatric Medical University

3. Leningrad Regional Center for the Prevention and Control of AIDS and Infectious Diseases

4. St. Petersburg State Pediatric Medical University

5. St. Petersburg Pasteur Institute

6. Polyclinic No. 48

7. Rospotrebnadzor Office for St. Petersburg

8. Rospotrebnadzor Office for Leningrad Region

9. Rospotrebnadzor Office for Novgorod Region

10. Rospotrebnadzor Office for Arkhangelsk Region; Northern State Medical University of the Ministry of Health of Russian Federation

11. Rospotrebnadzor Office for Vologda Region

12. Rospotrebnadzor Office for Kaliningrad Region

13. Rospotrebnadzor Office for Murmansk Region

14. Rospotrebnadzor Office for the Republic of Karelia

15. Rospotrebnadzor Office for Pskov Region

16. Rospotrebnadzor Office for Komi Republic

17. Rospotrebnadzor Office for Nenets Autonomous Okrug

18. Federal Center of Hygiene and Epidemiology

Abstract

Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection.

Publisher

SPb RAACI

Subject

Infectious Diseases,Immunology,Immunology and Allergy