AMIDOPHOSPHATE CONJUGATES GLYCEROLIPID DERIVATIVES OF 2’,3’-DIDEOXY-3’-THIACYTIDINE AND L-ALANINE ESTERS-Reference-Cited by-同舟云学术

AMIDOPHOSPHATE CONJUGATES GLYCEROLIPID DERIVATIVES OF 2’,3’-DIDEOXY-3’-THIACYTIDINE AND L-ALANINE ESTERS

Published:2022 Issue:2022-20 Volume:1 Page:42-44
ISSN:2312-640X
Container-title:BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES
language:ru
Short-container-title:

Author:

Vojtik K.D.¹,Shchelkonogov V.A.¹,Shastina N.S.¹

Affiliation:

1. MIREA-Russian Technological University (ITHT named after M.V. Lomonosov)

Abstract

In the course of the study, new derivatives of 2’,3’-dideoxy-3’-thiacytidine (3TC) based on 1,3-dipalmitoylglycerin were synthesized, modified at the phosphorus center with a number of L-alanine esters. Some of the conjugates showed significant antiretroviral activity and low cytotoxicity.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

CO LTD "EXPO-BIOHIM-TEXNOLOGIES"

Subject

General Medicine

Reference4 articles.

1. Gu S., Zhu Y., Wang C., et al. Recent discoveries in HIV-1 reverse transcriptase inhibitors. // Curr. Opin. Pharmacol. –2020. –V. 54, –P. 166-172.

2. 2. Lambert D.M. Rationale and applications of lipids as prodrug carriers. // Eur. J. Pharm. Sci. –2000. –V. 11 (Suppl. 2), – P. S15–S27.

3. 3. Shastina N.S., Maltseva T. Yu., D’yakova L.N., et al. Synthesis, properties, and anti-HIV activity of new lipophilic 3'-azido-3'-deoxythymidine conjugates containing functional phosphoric linkages. // Russ. J. Bioorg. Chem. –2013. – V. 39, No 2. – P. 161-169 (in Russ.).

4. 4. Darnotuk E.S., Siniavin A.E., Shulga N.V., et al. Phosphoramidate conjugates of 3’-azido-3’-deoxythymidine glycerolipid derivatives and amino acid esters: synthesis and anti-HIV activity. // Med.Chem.Res. –2021. –V. 30, –P. 664-671.