GENE-ACTIVATED MATRIСES IMPREGNATED WITH POLYPLEXES WITH BMP-2 GENE FOR BONE REGENERATION-Reference-Cited by-同舟云学术

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GENE-ACTIVATED MATRIСES IMPREGNATED WITH POLYPLEXES WITH BMP-2 GENE FOR BONE REGENERATION

Published:2022 Issue:2022-20 Volume:1 Page:20-21
ISSN:2312-640X
Container-title:BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES
language:ru
Short-container-title:

Author:

Khvorostina M.A.¹,Mokrousova V.O.²,Grigoriev T.E.³,Zagoskin Yu.D.³,Chvalun S.N.³,Bukharova T.B.²,Goldshtein D.V.²

Affiliation:

1. Research Centre for Medical Genetics, Institute of Photon Technologies of Federal Scientific Research Centre “Crystallog-raphy and Photonics”, Russian Academy of Sciences

2. Research Centre for Medical Genetics

3. National Research Centre "Kurchatov Institute"

Abstract

Gene-activated matrices based on chitosan hydrogel and polylactide particles impreg-nated with polyplexes with BMP-2 gene have been developed for bone regeneration. The obtained matrices have a significant osteoinductive effect on MSCs: extracellular matrix mineralization, an increase in gene expression and BMP-2 and ALPL proteins production are observed.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

CO LTD "EXPO-BIOHIM-TEXNOLOGIES"

Subject

General Medicine

Reference2 articles.

1. 1. Nedorubova I. A., Bukharova T. B., Vasilyev A.V.et al. Non-viral delivery of the BMP2 gene for bone regeneration //Genes and Cells. 2020. Vol. 15. No. 4. P. 33-39.

2. 2. Nedorubova I.A. Bukharova T.B., Vasilyev A.V.et al. Development of osteoplastic material impregnated with plasmid encoding bone morphogenetic protein-2 //Appl Bio-chem Microbiol. 2021. Vol. 57. No. 7. P. 818-822.

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