Stability Indicating Double Divisor Spectrophotometric Method for determination of Diloxanide Furoate and Metronidazole in Their Binary Mixture-Reference-Cited by-同舟云学术

Stability Indicating Double Divisor Spectrophotometric Method for determination of Diloxanide Furoate and Metronidazole in Their Binary Mixture

Published:2023-09-19 Issue:2 Volume:1 Page:37-48
ISSN:3005-480X
Container-title:International Journal of Clinical Medical Research
language:en
Short-container-title:IJCMR

Author:

Abdelrahman Maha M.,Ali Nouruddin W.,Abbas Samah S.,Zaazaa Hala E.,Abdelkawy M.

Abstract

<span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;">Diloxanide furoate (DXF) and Metronidazole (MTZ) are commonly combined as a binary mixture for the treatment of a variety of diseases brought on by bacteria and parasites including <span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; background: white;">amoebiasis and giardiasis. Different analytical methods were established for determination of both DXF and MTZ, <span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;">However, only one chemometric spectrophotometric method was established for their stability indicating determination which involves problematical steps and specific software program. Herein, <span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; letter-spacing: -.2pt;">double divisor ratio spectra derivative (DDRSD) method<span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;"> is exploited for quantification of DXF and MTZ in presence of DXF-degradation products (FUR and DEG). The recommended <span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; letter-spacing: -.2pt;">DDRSD<span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;"> method is linear over the range of <span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi;">2–25 and 1–25 µg/mL for DXF and MTZ, correspondingly. Additionally, the suggested method was effectively employed to their pharmaceutical formulations with good findings. Besides, the recommended DDRSD<span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;"> method was validated <span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi;">conforming to ICH guidelines. The introduced DDRSD<span style="font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;"> method is simple, selective, and economic and could be implemented for quality control samples of the studied drugs.

Publisher

Pharaoh Academy International Publishing Co., Limited

Link

https://www.pharaohacademy.com/1/2/8/pdf

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