Assessment of serum Pentraxin3 level in Iraq patients with and without Diabetic Retinopathy

Abstract

Diabetic retinopathy is the main cause of vision loss worldwide. It is considered one of the most severe diabetic microvascular complications affecting the retina's blood vessels due to prolonged hyperglycemia. Pentraxin 3 is an acute-phase glycoprotein that is correlated with inflammation. Inflammation is mechanistically involved in the development of diabetic retinopathy. This study aims to measure serum pentraxin3 levels in type 2 diabetic patients with and without retinopathy and compare their levels to controls. Also, investigate the relationship between circulating pentraxin3 and the development of diabetic retinopathy. This case–control study included one hundred and twenty (120) individuals aged 40 to 70 years. Individuals were divided into 3 groups: Group 1 included 40 types 2 diabetic patients with retinopathy, group 2 included 40 type 2 diabetic patients without retinopathy and group 3- included 40 persons as controls. Significant increase in the mean value of serum pentraxin3 in the diabetic patient with retinopathy as compared to diabetic patients with and without retinopathy as compared to and control(p=0.000) as well as a significant increase in the mean value of serum pentraxin3 in the diabetic patient with retinopathy as compared to diabetic patients without retinopathy (p=0.000). In addition, a significant positive correlation was found between serum pentraxin3 level and HbA1C in diabetic patients with retinopathy group (r=0.936, p= 0.0001). Higher serum level of pentraxin 3 in diabetic patients with retinopathy and its association with poor glycemic control, as well as pentraxin 3, is an acute-phase reactant, so serum pentraxin 3 levels may have a significant role in the initiation and development of diabetic retinopathy. Keywords: diabetes mellitus, diabetic retinopathy, pentraxin‑3.