Antibacterial and anti-biofilm action of cobalt oxide nanoparticles beside persister Pseudomonas Aeruginosa isolates

Abstract

Persister cells of Pseudomonas aeruginosa have developed a wide-reaching public health problem. Although this is a medical concern, there is currently no effective means to remove P. aeruginosa persister cells. Nanoparticles containing cobalt oxide (Co3O4-NPs) were examined for their ability to impact the formation of biofilms and inhibit the growth of bacteria. Researchers found that Co3o4-NPs were effective against P. aeruginosa, with inhibition zones ranging from 11 to 19 mm and MIC (Minimum Inhibition Concentration) results of 156 to 312 g/ml. The Co3O4-NPs with a titration of 10 mg/mL (76.54 percent) had the maximum biofilm suppression activity, while a titration of 0.156 mg/ml had the lowest (11.50 percent). According to the findings, P. aeruginosa biofilms and persister cells can benefit from applying co3o4-NPs. Keywords: Persister cell, SEM, co3o4-NPs, Anti-biofilm action