Effect of material tramadol on some blood components of laboratory rats

Abstract

The current study deal with the effect of tramadol injections on body weight and some blood components in 40 male laboratory rats, divided into four groups. The first group, G1 represents the control group. The second group G2 and the third group G3 were injected with a concentration of 20 and 40 mg/100 g of body weight, respectively, and the fourth group G4 was injected at a concentration of 80 mg / 100 g of body weight for ten days respectively. The current study results showed a significant decrease in the weights of rats injected with tramadol compared to the control group. Also, there was a significant decrease in the numbers of RBC, PLT, MID#, and GRAN#, respectively. The concentrations of each of the following constants: HGB, HCT, MCV, MCH, and MCHC showed a significant decrease in their values; except for MCV, the decrease was not significant, and the results of this study also recorded a significant increase in the white blood cells count as well as the number of lymphocytes, and there was an increase in both RDW-CV & RDW-SD. Keywords. Body weight, tramadol, RBC, WBC, PLT.