Hepatoprotective effect of Thyme aqueous extract in Acetaminophen induces hepatotoxicity in male rats.

Abstract

Thyme vulgaris is effective in treating acetaminophen toxicity in clinical trials. The present study investigates Thyme aqueous extract's effect on rats poisoned with Acetaminophen. In this study, the data were obtained from male Wister rats. Animals were divided into three groups: distilled water, acetaminophen (1mg/ kg), and aqueous thyme extract (400 mg/kg). All animals were orally treated for seven days respectively. The animal was sacrificed on the eighth day. ALT, AST, GSH, TAC, and Caspase3 were all measured in plasma obtained from heart-derived blood samples centrifuged to determine plasma levels of these enzymes and other antioxidants, malondialdehyde precursors (MDA). Liver enzyme levels were reduced, total antioxidant levels were increased, and an aqueous extract of thyme compensated for glutathione levels. Caspase3 levels were also reduced. Acetaminophen-induced liver tissue damage and inflammatory cell damage were considerably lessened by Aqueous Thyme extract treatment. To protect the liver from Acetaminophen-induced hepatotoxicity, aqueous Thyme extract was found to be beneficial. Keywords: Acetaminophen, Hepatotoxicity, Thyme aqueous extract, Histopathology