Affiliation:
1. Department of Biology, University of Baghdad, Iraq
Abstract
Background: Systematic Lupus erythematosus (SLE) has been described as a
chronic inflammatory illness where chemokines play an essential role in its
pathogenesis CX3CL1and CX3CR1 are chemokines that described their crucial
role in immune response in SLE patients. Aim of the study: To evaluate the serum
level of CX3CL1- CX3CR1, C3, C4 & ESR Abs in SLE patients without treatment
and compare their level with those under treatment (hydroxychloroquine,predeslone 5-20mg, D3). Patients collecting and Methods: 120 females with
SLE and healthy, with ages ranging between 20-40 years, were involved in this
investigation from Medical City (Consultant of Arthritis, Consultant of Dermatology, Lobby of Hematology and Arthritis)/ Baghdad Teaching Hospital and from
Al-Imameen Al-Kazimeen Teaching Hospital from August 26 to October 18,
2021. The samples included 80females with SLE (40 females as early diagnosed
patients (G2) without treatment, 40 females as patients that received treatment
subjects (hydroxychloroquine, predeslone 5-20mg, D3) (G3), while the control
group included 40 healthy females (G1). Five mL of venous blood were obtained
from patients and healthy females for measuring C3, C4, ESR and serum levels of
CX3CL1 and CX3CR1, which were measured using the ELISA method. Results:
Our findings demonstrated a significant increase in the serum levels of CX3CL1,
CX3CR1, and ESR. Also, there were significant decreases in serum levels of C3
and C4 in SLE patients (with and without treatment) compared to the control
group, and a significant difference was detected between SLE patients without
treatment and patients receiving treatment. Conclusion: Based on our results,
CX3CL1 and CX3CR1 chemokines may have a role in the pathogenesis of SLE as
they are increased in SLE patients. In addition, serum CX3CL1 levels can be used
as an independent biomarker of SLE activity. Furthermore, low levels of c3 and c4
and high levels of ESR are considered diagnostic indicators of SLE disease in
people.
Keywords: Systemic lupus erythematosus, CX3CL1; CX3CR1. C3,C4
Subject
Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology
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5. Bionatura http://dx.doi.org/10.21931/RB/ 2023.08.01.21 7