The study of some biochemical parameters in the serum of infected and recovered patients with COVID-19

Abstract

Few biochemical and immunological studies have been conducted on Iraqis infected with novel coronaviruses, and also Patients' post-recovery condition is unknown. Therefore, we aimed to study the impact of COVID-19 on some biochemical compounds in the serum of the infected subjects and to follow up the impact after 6-7 months. The research was conducted in Baghdad-Iraq from October to December 2021, and the study included four groups (each group consisted of 20 subjects): Group (A) Infected subjects without vaccination; group (B) Recovered subjects without vaccination; group (C) Recovered subjects after vaccination; and group (D) Non-infected subjects after vaccination. Subjects with COVID-19 infection confirmed by PCR and vaccinated individuals received the same type of vaccine. The authors measured some positive acute phase reactants (ferritin, C-reactive protein, and D-dimer), antibodies (IgM and IgG), and enzymes (LDH, AST, and ALT) in the subjects' serum. The study result showed an Increase in ferritin, CRP, D-dimer and LDH levels in the serum of infected subjects (group A). The antibody levels in the four groups were elevated, while the liver enzymes (ALT and AST) were in the normal values. Elevation of LDH level also in the serum of recovered subjects (groups B and C). Elevated ferritin, CRP, and D-dimer levels may not remain in infected patients after recovery from COVID-19 except for LDH, which is still elevated in some Iraqi subjects in Baghdad. Keywords: Iraq, COVID-19, Vaccine, Acute Phase Reactants, Antibodies, Liver enzymes