Affiliation:
1. Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences
2. Pacific State Medical University
Abstract
The review presents data on the use of carotenoids in the most threatening pathological conditions. The therapeutic and preventive effect of carotenoids is due to the inactivation of active oxygen species and free radicals. By eliminating the phenomena and consequences of oxidative stress, carotenoids are effective both in treating metabolic disorders in diabetes mellitus and abdominal obesity, and in reducing the risk of cardiovascular diseases. Diets enriched with carotenoids have a wide range of anti-cancer effects, apoptosis modulations and metastasis blocks. Carotenoids protect dopaminergic neurons of the brain from oxidative damage and reduce the severity of neurodegenerative disorders, Alzheimer's and Parkinson's diseases. However, carotenoids have limited bioavailability due to their low water solubility. Future research should be directed to the development of medicinal forms of carotene-containing phytopreparations that don’t have such disadvantage.
Publisher
Pacific State Medical University
Reference48 articles.
1. Rodriguez-Concepcion M, Avalos J, Bonet ML, Boronat A, Gomez-Gomez L, Hornero-Mendez D, Limon MC, MeléndezMartínez AJ, Olmedilla-Alonso B, Palou A, Ribot J, Rodrigo MJ, Zacarias L, Zhu C. A global perspective on carotenoids: metabolism, biotechnology and benefits for nutrition and health. Progress in lipid research.2018;70:62–93. doi.org/10.1016/j.plipres.2018.04.004
2. Hashimoto H, Uragami C, Cogdell RJ. Chapter 4. Carotenoids and photosynthesis. In: Stange C, editor. Carotenoids in Nature. Subcellular biochemistry 79. New York: Springer International Publishing. 2016; P. 111–39. doi 10.1007/978-3-319-39126-7_4
3. Deyneka VI, Shaposhnikov AA, Deyneka LA, Guseva TS, Vostrikova SM, Shentseva EA, Zakirova LR. Carotenoids: the structure, biological functions and perspectives of application. Belgorod state university scientific bulletin. Medicina. Pharmacy. 2008;6(46):19–25. In Rus URL: https://www.bsu.edu.ru/upload/iblock/06a/6_46_6.pdf (Дата обращения 10.07.21)
4. Meléndez-Martínez AJ, Mapelli-Brahm P, Hornero-Méndez D, Vicario IM. Structures, nomenclature and general chemistry of carotenoids and their esters. Mercadante AZ, ed. Carotenoid esters in foods: physical, chemical and biological properties, London: Royal society of chemistry; 2019:1–50. doi: 10.1039/978178801585100001
5. Maoka T. Carotenoids as natural functional pigments. Journal of natural medicine. 2020;74:1–16. Doi.org/10.1007/s11418019-01364-x
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