Vascular retinal pathology in women with preeclampsia and its combination with chronic arterial hypertension

Author:

Sorokin E. L.1,Kolenko O. V.2ORCID,Fil A. A.3

Affiliation:

1. The S. Fyodorov Eye Microsurgery Federal State Institution; Far Eastern State Medical University

2. The S. Fyodorov Eye Microsurgery Federal State Institution; Postgraduate Institute for Public Health Workers

3. The S. Fyodorov Eye Microsurgery Federal State Institution

Abstract

Aim. To investigate the incidence and structure of vascular retinal pathologies in women with preeclampsia and its combination with chronic arterial hypertension (AH).Methods. A total of 231 medical records of women with different pregnancy histories were studied by consecutive sampling. The first experimental group comprised women (n = 47) diagnosed with preeclampsia combined with chronic AH. The second experimental group comprised women (n = 48) with preeclampsia developed during pregnancy. The first comparison group included women with pregnancy-associated gestational AH. The second comparison group included women with edema and proteinuria during pregnancy but without AH. The control group consisted of women (n = 50) with normal pregnancy histories. The postpartum period ranged from 6 to 12 years.Results. The development of vascular retinal pathologies during the postpartum period occurred in 28 women in the general sample (12%). Retinal vein occlusions predominated in the structure of vascular retinal pathology (19 women, 19 eyes). Proliferative retinopathy was detected in 8 patients (8 eyes). In one case, a central retinal artery occlusion developed.Conclusions. The incidence of vascular retinal pathologies in the 1st and 2nd experimental groups comprised 21% and 25% respectively, which was statistically significantly higher than that in the control, 1st and 2nd comparison groups (4%, 4%, and 6% respectively, p < 0.01). The revealed significantly higher incidence of vascular retinal pathology in both experimental groups indicates the domineering role of preeclampsia and AH-associated pre-eclampsia in the development of vascular retinal pathologies. 

Publisher

Pacific State Medical University

Subject

General Medicine

Reference15 articles.

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2. Lambert G, Brichant JF, Hartstein G, Bonhomme V, Dewandre PY. Preeclampsia: an update. Acta anaesthesiologica Belgica. 2014;65(4):137–49.

3. Sergeeva ON, Chesnokova NP, Ponukalina EV, Rogozhina IE, Glukhova TN. Pathogenetic relationship between endothelial dysfunctionand disorders of blood coagulation potential in pregnancy complicated by pre-eclampsia. Annals of the Russian Academy of Medical Sciences. 2015;70(5):599–603. (In Russ.). doi: 10.15690/vramn.v70.i5.1448

4. Sukhikh GТ, Vikhlyaeva YeM, Vanko LV, Khodzhayeva ZS, Shurshalina AV, Kholin AM. Endothelial dysfunction in the genesis of perinatal pathology. Obstetrics and gynecology. 2008;(5):3–7. (In Russ.)

5. Chambers JC, Fusi L, Malik IS, Haskard DO, Swiet MDe, Kooner JS. Association of maternal endothelial dysfunction with preeclampsia. JAMA. 2001;285(12):1607–12. doi: 10.1001/jama.285.12.1607

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