Affiliation:
1. Pacific State Medical University;
Primorskiy Center of Eye Microsurgery
2. Pacific State Medical University
Abstract
Objective: To detect early morphological and functional signs of neurodegeneration of the retina in patients with type 2 diabetes mellitus (DM) without signs of diabetic retinopathy (DR), to determine the presence and nature of the relationship between the studied parameters.Methods: The study included 30 patients with type 2 DM without DR (main group) and 30 healthy individuals (control group). Optical coherence tomography and microperimetry were performed.Results: In the main group, a significant decrease in the average photosensitivity of the retina and a decrease in its photosensitivity in the fovea and in the upper, lower, and temporal quadrants of parafovea were revealed. A significant difference between the groups was also recorded in the thickness of the inner layers of the retina in the temporal quadrant of parafovea. There was also a significant difference in the volume of focal loss of retinal ganglion cells.Conclusions: Neurodegenerative and related functional changes in the retina were revealed in patients with type 2 DM without signs of DR. Retinal neurodegeneration is one of the reasons for the deterioration of visual function in patients with DM and can aggravate the prognosis of the disease. Optical coherence tomography and microperimetry can be used for early diagnosis and monitoring of this process.
Publisher
Pacific State Medical University
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