Affiliation:
1. Departments of Pediatric Dermatology and
2. Pediatric Surgery, Sydney Children’s Hospital, Randwick, Australia
Abstract
OBJECTIVE:
Timolol maleate 0.5% gel is a safe and effective medication for treating superficial infantile hemangiomas (IHs) in infants with a median age of 9 weeks.
METHODS:
Forty-one infants who had superficial IHs without ulceration and not near mucosal surfaces were recruited and randomly assigned to placebo and treatment (timolol maleate 0.5% gel) groups. Efficacy was assessed by performing blinded volume measurements at weeks 0, 1, 2, 3, 4, 8, 12, 16, 20, and 24 and blinded investigator photograph scoring at weeks 0, 12, and 24. Safety was assessed by measuring heart rate and systolic and diastolic blood pressure at weeks 0, 1, 2, 3, 4, 8, 12, 16, 20, and 24.
RESULTS:
Fifteen of the 19 infants receiving treatment and 17 of the 22 infants receiving placebo completed the study. Significant color change on the blinded photographic scores was noted at week 24 of the study (P = .003). There was a significantly higher proportion of treated IHs that reduced in size by >5% at weeks 20 and 24 (P < .02). The predicted proportion of IH volume change was also significantly less for treated IHs from week 16 onward when compared with placebo (P < .05). There was no significant variation in blood pressure and heart rate between the groups.
CONCLUSIONS:
Topical timolol maleate 0.5% gel with a maximum dose of 0.5 mg per day is a safe and effective option for small superficial IHs that have not ulcerated and are not on mucosal surfaces.
Publisher
American Academy of Pediatrics (AAP)
Subject
Pediatrics, Perinatology, and Child Health
Reference35 articles.
1. Strawberry hemangiomas; the natural history of the untreated lesion.;Jacobs;Calif Med,1957
2. A prospective study of infantile hemangiomas with a focus on incidence and risk factors.;Dickison;Pediatr Dermatol,2011
3. Infantile hemangiomas: how common are they? A systematic review of the medical literature.;Kilcline;Pediatr Dermatol,2008
4. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice.;Khan;J Clin Invest,2008
5. Growth characteristics of infantile hemangiomas: implications for management.;Chang;Pediatrics,2008
Cited by
124 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献