Affiliation:
1. *Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA
2. †Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA
Abstract
Sickle cell disease (SCD) is the most common inherited condition worldwide. In the United States, SCD affects 100,000 births every year, mostly persons of African descent. In SCD, red blood cells assume a sickle shape when deoxygenated. This leads to the occlusion of small blood vessels and decreased oxygenated blood flow, resulting in ischemic and thrombotic injury to various organs, which further leads to organ dysfunction. In pregnancy, patients with SCD are at an increased risk of vaso-occlusive crises, which further increases the risks of maternal, fetal, and neonatal morbidity and mortality.
Publisher
American Academy of Pediatrics (AAP)
Subject
Pediatrics, Perinatology and Child Health
Reference34 articles.
1. Sickle cell disease;Piel;N Engl J Med,2017
2. Centers for Disease Control and Prevention. Data & Statistics on Sickle Cell Disease. https://www.cdc.gov/ncbddd/sicklecell/data.html. Accessed April 14, 2023
3. Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease;Hussein;Cochrane Database Syst Rev,2021
4. The current state of sickle cell trait: implications for reproductive and genetic counseling;Pecker;Blood,2018
5. The vaso-occlusive pain crisis in sickle cell disease: definition, pathophysiology, and management;Darbari;Eur J Haematol,2020