Growth of Preterm Infants Fed Nutrient-Enriched or Term Formula After Hospital Discharge

Author:

Carver Jane D.1,Wu Paul Y. K.2,Hall Robert T.3,Ziegler Ekhard E.4,Sosa Roberto5,Jacobs Joan6,Baggs Geraldine6,Auestad Nancy6,Lloyd Beate6

Affiliation:

1. From the University of South Florida College of Medicine, Department of Pediatrics, Division of Neonatology, Tampa, Florida;

2. Los Angeles County and University of Southern California School of Medicine, Division of Neonatal-Perinatal Medicine, Los Angeles, California;

3. Children's Mercy Hospital, Kansas City, Missouri;

4. University of Iowa Hospitals and Clinics, Iowa City, Iowa;

5. All Children's Hospital, St Petersburg, Florida; and

6. Ross Products Division, Abbott Laboratories, Columbus, Ohio.

Abstract

Objective. At hospital discharge, preterm infants may have low body stores of nutrients, deficient bone mineralization, and an accumulated energy deficit. This double-blind, randomized study evaluated the growth of premature infants with birth weights <1800 g who were fed a 22 kcal/fl oz nutrient-enriched postdischarge formula (PDF) or a 20 kcal/fl oz term-infant formula (TF) from hospital discharge to 12 months' corrected age (CA). Methods. Infants were randomized to PDF or TF a few days before hospital discharge with stratification by gender and birth weight (<1250 g or ≥1250 g). The formulas were fed to 12 months' CA. Growth was evaluated using analysis of variance controlling for site, feeding, gender, and birth weight group. Interaction effects were also assessed. Secondary analyses included a repeated measures analysis and growth modeling. Results. One hundred twenty-five infants were randomized; 74 completed to 6 months' CA and 53 to 12 months' CA. PDF-fed infants weighed more than TF-fed infants at 1 and 2 months' CA, gained more weight from study day 1 to 1 and 2 months' CA, and were longer at 3 months' CA. There were significant interactions between feeding and birth weight group—among infants with birth weights <1250 g, those fed PDF weighed more at 6 months' CA, were longer at 6 months' CA, had larger head circumferences at term 1, 3, 6, and 12 months' CA, and gained more in head circumference from study day 1 to term and to 1 month CA. The repeated measures and growth modeling analyses confirmed the analysis of variance results. The PDF formula seemed to be of particular benefit for the growth of male infants. Infants fed the PDF consumed less formula and had higher protein intakes at several time points. Energy intakes, however, were not different. Conclusions. Growth was improved in preterm infants fed a nutrient-enriched postdischarge formula after hospital discharge to 12 months' CA. Beneficial effects were most evident among infants with birth weights <1250 g, particularly for head circumference measurements.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Reference46 articles.

1. Nutrition and growth analysis of very low birthweight infants.;Fenton;Pediatrics,1990

2. Very low birthweight outcomes of the National Institute of Child Health and Human Developmental Neonatal Network.;Hack;Pediatrics,1991

3. Increased bone mineral content of preterm infants fed with a nutrient enriched formula after discharge from hospital.;Bishop;Arch Dis Child,1993

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3