Severe Infantile Hypercalcemia Associated With Williams Syndrome Successfully Treated With Intravenously Administered Pamidronate-Reference-Cited by-同舟云学术

Severe Infantile Hypercalcemia Associated With Williams Syndrome Successfully Treated With Intravenously Administered Pamidronate

Published:2004-10-01 Issue:4 Volume:114 Page:1091-1095
ISSN:0031-4005
Container-title:Pediatrics
language:en
Short-container-title:

Author:

Cagle Andrew P.¹,Waguespack Steven G.²,Buckingham Bruce A.³,Shankar R. Ravi¹,DiMeglio Linda A.¹

Affiliation:

1. Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, Indiana

2. Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas M. D. Anderson Cancer Center, Houston, Texas

3. Section of Pediatric Endocrinology and Diabetology, Stanford University School of Medicine, Stanford, California

Abstract

Infantile hypercalcemia occurs in ∼15% of children with Williams syndrome (WS) and is typically not clinically severe. We report on 3 children with WS (confirmed with fluorescent in situ hybridization probes) who presented with severe symptomatic hypercalcemia. The first patient's severe hypercalcemia resolved with traditional therapies, whereas the subsequent 2 patients were treated with intravenously administered pamidronate after traditional measures proved only partially successful. Besides asymptomatic mild hypocalcemia, there were no complications resulting from pamidronate administration. We conclude that WS-associated hypercalcemia can be quite severe and symptomatic and that it can be successfully and safely treated with intravenously administered bisphosphonate in some cases.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Link

https://publications.aap.org/pediatrics/article-pdf/114/4/1091/1020046/zpe01004001091.pdf

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