Abstract
Infants and toddlers with multiple unexplained fractures are often victims of inflicted injury. However, several medical conditions can also cause multiple fractures in children in this age group. In this report, the differential diagnosis of multiple fractures is presented, and diagnostic testing available to the clinician is discussed. The hypothetical entity “temporary brittle-bone disease” is examined also. Although frequently offered in court cases as a cause of multiple infant fractures, there is no evidence that this condition actually exists.
Publisher
American Academy of Pediatrics (AAP)
Subject
Pediatrics, Perinatology, and Child Health
Reference34 articles.
1. Shea-Landry GL, Cole DE. Psychosocial aspects of osteogenesis imperfecta. CMAJ. 1986;135:977–981
2. Kleinman PK. Skeletal trauma: general considerations. In: Kleinman PK, ed. Diagnostic Imaging of Child Abuse. 2nd ed. St Louis, MO: Mosby; 1998:8–25
3. Byers PH, Steiner RD. Osteogenesis imperfecta. Annu Rev Med. 1992;43:269–282
4. Wallis GA, Starman BJ, Zinn AB, Byers PH. Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism for a lethal point mutation in the alpha 1(I) gene (COL1A1) of type I collagen in a parent. Am J Hum Genet. 1990;46:1034–1040
5. Barsh GS, Byers PH. Reduced secretion of structurally abnormal type I procollagen in a form of osteogenesis imperfecta. Proc Natl Acad Sci U S A. 1981;78:5142–5146
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