Calcium and Vitamin D: What Is Known About the Effects on Growing Bone-Reference-Cited by-同舟云学术

Calcium and Vitamin D: What Is Known About the Effects on Growing Bone

Published:2007-03-01 Issue:Supplement_2 Volume:119 Page:S141-S144
ISSN:0031-4005
Container-title:Pediatrics
language:en
Short-container-title:

Author:

Demay Marie B.¹,Sabbagh Yves¹,Carpenter Thomas O.²

Affiliation:

1. Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

2. Department of Pediatrics, Yale University, New Haven, Connecticut

Abstract

The objective of these investigations was to determine if the receptor-dependent effects of 1,25-dihydroxyvitamin D were essential for normal skeletal growth. Mice with targeted ablation of the vitamin D receptor were engineered, and the skeletal consequences of vitamin D receptor ablation were studied in the presence of normal and abnormal mineral ion homeostasis. Prevention of abnormal mineral ion homeostasis resulted in the development of a normal skeleton in the absence of a functional vitamin D receptor. The metabolic cause of rickets was found to be hypophosphatemia. The major receptor-dependent actions of 1,25-dihydroxyvitamin D on skeletal development are indirect and are a reflection of the role of this hormone on intestinal calcium absorption.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Link

https://publications.aap.org/pediatrics/article-pdf/119/Supplement_2/S141/889373/zpe6030700s141.pdf

Reference17 articles.

1. Haussler MR, Whitfield GK, Haussler CA, The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res. 1998;13:325–349

2. Li YC, Pirro AE, Amling M, et al. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A. 1997;94:9831–9835

3. Thomas M, Demay M. Vitamin D deficiency and disorders of vitamin D metabolism. Endocrinol Metab Clin North Am. 2000;29:611–627, viii

4. Kollenkirchen U, Fox J, Walters MR. Normocalcemia without hyperparathyroidism in vitamin D-deficient rats. J Bone Miner Res. 1991;6:273–278

5. Li YC, Amling M, Pirro AE, et al. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology. 1998;139:4391–4396

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dietary content and combined training, but not daily physical activity, are associated with 6-month bone mineral changes in adolescents with obesity: A Secondary analysis of the PAC-MAnO trial;European Journal of Pediatrics;2024-06-27

2. The structural and functional dynamics of vitamin D and its receptor with their associated genes targeting diseases;Obesity Medicine;2023-09

3. Dilemmas in establishing preterm enteral feeding: where do we start and how fast do we go?;Journal of Perinatology;2023-05-11

4. Burosumab for Pediatric X-Linked Hypophosphatemia;Current Osteoporosis Reports;2021-05-10

5. Congenital Conditions of Hypophosphatemia in Children;Calcified Tissue International;2020-04-23