Life-Threatening Sepsis Caused by Burkholderia cepacia From Contaminated Intravenous Flush Solutions Prepared by a Compounding Pharmacy in Another State-Reference-Cited by-同舟云学术

Life-Threatening Sepsis Caused by Burkholderia cepacia From Contaminated Intravenous Flush Solutions Prepared by a Compounding Pharmacy in Another State

Published:2006-07-01 Issue:1 Volume:118 Page:e212-e215
ISSN:0031-4005
Container-title:Pediatrics
language:en
Short-container-title:

Author:

Held Melissa R.¹,Begier Elizabeth M.²³,Beardsley Diana S.⁴,Browne Frederick A.⁵,Martinello Richard A.¹⁶⁷,Baltimore Robert S.¹⁸,McDonald L. Clifford⁹,Jensen Bette⁹,Hadler James L.²,Dembry Louise-Marie⁷⁸

Affiliation:

1. Department of Pediatrics, Division of Infectious Diseases

2. Infectious Disease Division, Connecticut Department of Public Health, Hartford, Connecticut

3. Epidemic Intelligence Service Program

4. Department of Pediatrics, Division of Hematology/Oncology

5. Department of Laboratory Medicine, Yale-New Haven Hospital, New Haven, Connecticut

6. Department of Internal Medicine and the Clinical Epidemiological Research Center, VA Connecticut Healthcare System, West Haven, Connecticut

7. Internal Medicine

8. Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut

9. Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding. Bacterial isolates from the patients' blood cultures and the infusate were indistinguishable by pulsed-field gel electrophoresis. Proper quality controls at a local and national level are important for ensuring safe delivery of compounded medications to patients in all settings, including those outside health care facilities.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology, and Child Health

Link

https://publications.aap.org/pediatrics/article-pdf/118/1/e212/1011261/zpe0070600e212.pdf

Reference23 articles.

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3. Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33:2233–2239

4. Centers for Disease Control and Prevention. Manufacturer's recall of nasal spray contaminated with Burkholderia cepacia complex. MMWR Morb Mortal Wkly Rep. 2004;53:246

5. Centers for Disease Control and Prevention. Notice to readers: nosocomial Burkholderia cepacia infections associated with exposure to sublingual probes—Texas 2004. MMWR Morb Mortal Wkly Rep. 2004;53:796

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