Affiliation:
1. University of Colorado Medical Center, Denver, Colorado
Abstract
Though hypoglycemia has been a common clinical condition known to affect human brain development, little has been done to define the resultant brain biochemical alterations. Because a controlled study of hypoglycemia in the newborn human infant is impossible, the infant rat was chosen as a model. Hypoglycemia induced once daily for 18 days following birth resulted in a generalized diminution of brain weight, cellularity, and protein content. The rate of formation of the myelin lipid sulfatide was decreased, as was the quantity of cerebroside-sulfatide in brains of hypoglycemic animals. Phospholipids, gangliosides, and cholesterol were decreased only in proportion to the decrease in brain weight. Brain glucose and glycogen concentrations were low in the brains of hypoglycemic animals, although ATP and phosphocreatine levels were not decreased.
Publisher
American Academy of Pediatrics (AAP)
Subject
Pediatrics, Perinatology and Child Health
Cited by
13 articles.
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2. Macrosomia and Neonatology;Maternal Obesity and Pregnancy;2012
3. Disorders of the perinatal period;Greenfield's Neuropathology Eighth Edition. 2 Volume Set and DVD;2008-02-29
4. Glycemic Control in Prepubertal Years;Diabetes Care;2003-04-01
5. Kreislaufstörungen des ZNS;Neuropathologie;2002