HYPERTENSION AND HYPOKALEMIC ALKALOSIS ASSOCIATED WITH UNDERPRODUCTION OF ALDOSTERONE

Author:

Aarskog Dagfinn1,Støa Karl F.1,Thorsen Thor1,Wefring Karl W.1

Affiliation:

1. University of Bergen, School of Medicine, Department of Paediatrics and the Hormone Laboratory, Bergen, Norway

Abstract

A 10-year-old girl presented with a syndrome characterized by hypertension, hypokalemic alkalosis, and inability of the kidneys to concentrate the urine and conserve potassium. The aldosterone excretion and secretion rate were subnormal to low both when she was on a liberal sodium intake and on restricted sodium intake. Treatment with Triamterene resulted in potassium retention , restoration of normal serum potassium level, abolition of the alkalosis, normalization of the blood pressure, and increase of aldosterone secretion rate. The differential diagnosis in conditions associated with hypokalemic alkalosis and renal wastage of potassium is discussed.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Two sporadic cases of liddle’s syndrome caused by de novo ENaC mutations;American Journal of Kidney Diseases;2001-03

2. Growth Hormone Neurosecretory Dysfunction: Update;Basic and Clinical Aspects of Growth Hormone;1988

3. Blood Pressure and Hypertension in Childhood and Adolescence;Advances in Internal Medicine and Pediatrics/Ergebnisse der Inneren Medizin und Kinderheilkunde;1979

4. Mineralocorticoidsyndrome;Ergebnisse der Inneren Medizin und Kinderheilkunde;1972

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