A Method for Interdicting the Development of Severe Jaundice in Newborns by Inhibiting the Production of Bilirubin

Author:

Kappas Attallah1

Affiliation:

1. From the Rockefeller University Hospital, New York, New York

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Reference20 articles.

1. Kappas A, Drummond GS. Control of heme metabolism with synthetic metalloporphyrins. J Clin Invest.1986;77:335–339

2. Drummond GS, Kappas A. Prevention of neonatal hyperbilirubinemia by Sn-protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci USA.1981;78:6466–6470

3. Yoshinaga T, Sassa S, Kappas A. Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation. J Biol Chem.1982;257:7778–7785

4. Kappas A, Simionatto CS, Drummond GS, Sassa S, Anderson KE. The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin. Proc Natl Acad Sci USA.1985;82:896–900

5. Sardana MK, Kappas A. Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Proc Natl Acad Sci USA.1987;84:2464–2468

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