A STUDY OF THE POSSIBLE RELATIONSHIP OF PROGESTERONE TO COLIC
Author:
Clark Robert L.1,
Ganis Frank M.1,
Bradford William L.1
Affiliation:
1. Departments of Pediatrics and Biochemistry, University of Rochester, School of Medicine and Dentistry, Rochester, New York
Abstract
A series of 15 noncolic infants ranging in age from 6 days to 3 months was studied to determine pregnanediol glucuronide (PDG) excretion in urine. All these infants showed appreciable PDG spots by sensitive chromatographic techniques. In contrast, eight "colic" infants were studied, and it was found that these infants excreted none or only trace amounts of PDG in their urines. Seven other "colic" infants also showed no urinary PDG spots before hormone administration but demonstrated remission of symptoms and chromatographic spots after treatment. It is suggested that one cause of colic may involve progesterone deficiency and that in such instances the symptoms may be alleviated by the administration of a short course of oral progestational hormone.
Publisher
American Academy of Pediatrics (AAP)
Subject
Pediatrics, Perinatology, and Child Health
Cited by
1 articles.
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1. Functional Bowel Disturbances in Childhood;Pathogenesis of Functional Bowel Disease;1989