Blisters and Erosions in the Neonate

Abstract

Blisters and erosions in the newborn period may be the primary manifestation of several diseases that include infectious, inherited, or congenital conditions and represent a diagnostic challenge for pediatricians and dermatologists alike. In some cases, the lesions are benign and transient, but they may also be the first presentation of a lifelong skin disease or the manifestation of a serious systemic illness. Early recognition and evaluation is critical for effective treatment of the conditions that are rapidly progressive or fatal without prompt intervention. This review offers an approach to the diagnosis of neonates presenting with blisters or erosions, emphasizing morphologic features and confirmatory diagnostic tests, and touches on basic principles for management.