Exercise-Induced Bronchial Lability in Wheezy Children and Their Families

Author:

Godfrey Simon1,König Peter1

Affiliation:

1. Department of Paediatrics and Neonatal Medicine, Hammersmith Hospital, London, England

Abstract

Studies have been carried out to investigate bronchial lability as assessed by means of standardized running exercise tests. It was found that children who had been wheezy as infants still had an abnormal degree of bronchial lability, even if they were asymptomatic, and closely resembled children who had continued to wheeze. The relatives of asthmatic children displayed a high incidence of bronchial lability. atopic diseases, and positive skin tests, and a similar incidence was found in the relatives of babies with wheezy bronchitis. The difference from a control population was particularly noticeable in the healthy relatives of wheezy children. Studies in monozygotic and dizygotic twins have shown a very high incidence of concordance for asthma, particularly when bronchial lability is taken into account. These studies suggest a common genetic basis for wheezing in childhood, based on the inheritance of bronchial lability. The difference in response of the actively asthmatic subject from that of other labile subjects suggests that additional environmental factors are necessary to interact with the inherited bronchial lability.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Approach to the Patient with Exercise-Induced Airway Narrowing;Middleton's Allergy: Principles and Practice;2009

2. Bronchial Hyperresponsiveness in Childhood;Immunology and Allergy Clinics of North America;1990-08

3. Clinical expression of bronchial hyperreactivity in children;Clinical Reviews in Allergy;1989-09

4. Lungenerkrankungen;Die Praxis der Sportmedizin in der Kinderheilkunde;1986

5. Pulmonary Diseases;Pediatric Sports Medicine for the Practitioner;1983

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