Changes and Possible Role of Neuropeptides in Iatrogenic Dry Eye

Abstract

Recently, the role of the corneal nerve in the pathogenesis of dry eye disease (DED) has been highlighted. Considering that neuropeptides are known as important mediators between the nervous and immune systems, neurogenic inflammation induced and regulated by neuropeptides secreted from nerve terminals is expected to be involved in the pathogenesis of DED. And iatrogenic DED has been recently spotlighted as an important field with increasing interest in DED that occurs after ocular surgery or contact lens use. In this paper, recent studies on the role of neuropeptides in the pathogenesis of DED, in particular, the changes and possible roles of neuropeptides in iatrogenic DED were reviewed.