Experimental Assessment of Absorbed Doses in Pathological Lesions during Radionuclide Therapy with 225Ac-PSMA-617 and 225Ac-DOTATATE-Reference-Cited by-同舟云学术

Experimental Assessment of Absorbed Doses in Pathological Lesions during Radionuclide Therapy with 225Ac-PSMA-617 and 225Ac-DOTATATE

Published:2023-12-29 Issue:4 Volume: Page:40-50
ISSN:1810-200X
Container-title:Meditsinskaya Fizika
language:
Short-container-title:Med. fiz.

Author:

Chipiga L. A.¹,Lavreshov D. D.²,Vodovatov A. V.³,Parunova E. N.²,Zvonova I. A.⁴,Petryakova A. V.⁵,Vazhenina D. A.⁶,Odintsova M. V.⁶,Nomokonova V. B.⁶,Stanzhevsky A. A.⁷,Maistrenko D. N.⁷

Affiliation:

1. P.V. Ramzaev Saint-Petersburg Research Institute of Radiation Hygiene;;A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies; Saint-Petersburg State Pediatric Medical University

2. Peter the Great St. Petersburg Polytechnic University

3. P.V. Ramzaev Saint-Petersburg Research Institute of Radiation Hygiene; V.A. Almazov National Medical Research Centre

4. P.V. Ramzaev Saint-Petersburg Research Institute of Radiation Hygiene

5. P.V. Ramzaev Saint-Petersburg Research Institute of Radiation Hygiene; The City Hospital No 40 of the Kurortny District

6. A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies

7. Saint-Petersburg State Pediatric Medical University

Abstract

Development of radiopharmaceutical therapy treatment plans considering biokinetics of radiopharmaceuticals and individual features of patients is necessary for the provision of radiation safety of the patients and increase in the efficacy of treatment. Hence, it is necessary to assess the absorbed doses in lesions (targets). The current study presents the method for the assessment of the absorbed doses in lesions considering the biological effectiveness of exposure for the radiopharmaceutical therapy with 225Ac-PSMA-617 and 225Ac-DOTATATE. Assessment of the absorbed doses was performed based on the analysis of the PET images of patients. Results of the study indicate that the absorbed doses for 225Ac-PSMA-617 and 225Ac-DOTATATE were in the range of 90-190 Gy-eq. and 30-500 Gy-eq. correspondingly. The lack of radiotoxicity and accumulation of required absorbed dose per treatment course indicates the efficiency of radiopharmaceutical therapy with 225Ac-PSMA-617 and 225Ac-DOTATATE.

Publisher

Association of Medical Physicists in Russia

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