Author:
Langer-Gould Annette M.,Gonzales Edlin Grisell,Smith Jessica B.,Li Bonnie H.,Nelson Lorene M.
Abstract
Background and ObjectivesThe goal of this work was to determine whether the prevalence of multiple sclerosis (MS) varies by race and ethnicity.MethodsWe conducted a retrospective cohort study of >2.6 million adults from the multiethnic, community-dwelling members of Kaiser Permanente Southern California. The complete electronic health records of individuals with at least 1 ICD-9 code for MS between January 1, 2008 and December 31, 2010 were reviewed. MS prevalence and 95% CIs stratified by age, sex, and race and ethnicity among 2010 members were estimated with binomial regression. Age- and sex-standardized prevalence was estimated according to the 2010 US Census population.ResultsWe identified 3,863 patients with MS. The average age of patients with prevalent MS was 51.7 years (SD 13.1 years), and 76.8% were women. The female preponderance was more pronounced among Black (81.2%) and Asian (83.6%) than White (76.3%) or Hispanic (74.5%) individuals with MS. Age- and sex-standardized MS prevalence per 100,000 was similarly high among Black (225.8, 95% CI 207.1–244.5) and White (237.7, 95% CI 228.2–247.2) and significantly lower among Hispanic (69.9, 95% CI 64.4–75.5) and Asian (22.6, 95% CI 17.1–28.1) persons. MS prevalence was highest between the ages of 35 and 64 years and declined after 65 years of age across all racial and ethnic groups. Among adults 18 to 24 years of age, the crude MS prevalence was low but was highest among Black and Hispanic young adults, lower in White people, and lowest in Asian/Pacific Islander individuals (48.5, 25.0, 18.0, and 7.1 per 100,000, respectively).DiscussionMS prevalence varies by race and ethnicity, being similarly high in White and Black and significantly lower in Hispanic and Asian persons in Southern California. Taken together with previous studies, these findings indicate that the burden of MS in the US Black community has long been underrecognized. More studies are needed to determine whether MS is an emerging disease among US Hispanic adults and whether MS susceptibility and prevalence vary among Hispanic or Asian individuals from different cultures or ancestral backgrounds.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference36 articles.
1. Incidence of multiple sclerosis in multiple racial and ethnic groups
2. US Census Bureau. The chance that two people chosen at random are of different race or ethnicity groups has increased since 2010. Accessed August 19, 2021. census.gov/library/stories/2021/08/2020-united-states-population-more-racially-ethnically-diverse-than-2010.html
3. Incidence and Prevalence of Multiple Sclerosis in the Americas: A Systematic Review
4. Incidence and prevalence of multiple sclerosis in Olmsted County, Minnesota, 1985–2000
5. Prevalence of multiple sclerosis in 19 Texas counties, 1998-2000;Williamson;J Environ Health.,2007
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