1. From the Translational Brain Science (M.T., S.P.M., A.J.S.), Institute of Metabolism and Systems Research, and Cancer Research (UK) Clinical Trials Unit (V.H.), University of Birmingham; Department of Neurology (M.T., A.J.S.) and Birmingham Neuro-Ophthalmology (S.P.M.), University Hospitals Birmingham NHS Foundation Trust; Centre for Endocrinology (M.T., A.J.S.), Diabetes and Metabolism, Birmingham Health Partners, UK.