Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up

Author:

Kipinoinen TeemuORCID,Toppala SiniORCID,Rinne Juha O.ORCID,Viitanen Matti H.ORCID,Jula Antti MORCID,Ekblad Laura LORCID

Abstract

Background and objectives:Chronic low-grade inflammation, commonly associated with cardiovascular diseases and risk factors, has been associated inconclusively with cognitive decline and dementia. The aim of our study was to evaluate whether low-grade inflammation, measured in midlife, is associated with a decline in cognitive performance after a 10-year follow-up. We hypothesized that low-grade inflammation, estimated by interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and high-sensitivity CRP (hs-CRP), is a predictor of cognitive decline in the general population.Methods:This prospective cohort study is based on a Finnish nationwide, population-based Health 2000Examination Survey, its supplemental examinations in 2000-2001 and the follow-up Health 2011Survey. Cognitive performance at baseline and at follow-up was assessed with categorical verbal fluency (VF), Word-list learning (WLL) and word-list delayed recall (WLDR). Baseline low-grade inflammation was measured with IL-6, TNF-α and hs-CRP in 2001. Associations between low-grade inflammation and cognitive performance were analyzed with multivariable linear models adjusted for age, sex, education, APOEε4 genotype, type 2 diabetes, hypertension, hypercholesterolemia, body mass index, depressive symptoms, smoking, and baseline cognition.Results:915 participants aged 45 to 74 years (median age 54, 55% women) were included in the analysis. Both higher IL-6 and TNF-α at baseline predicted poorer performance in VF and WLL at 10-year follow-up (VF: IL-6 β: -1.14, p=0.003, TNF-α β: -1.78, p=0.008; WLL: IL-6 β: -0.61, p=0.007, TNF-α β: -0.86, p=0.03). Elevated IL-6 also predicted a greater decline in VF and WLL after a 10-year follow-up (VF: β: -0.81, p=0.01; WLL: β: -0.53, p=0.008). Baseline TNF-α did not predict cognitive decline and hs-CRP did not predict cognitive performance or decline after 10-years.Discussion:Our results suggest that low-grade inflammation in midlife is an independent risk factor of poorer cognitive performance later in life. Of the studied markers IL-6 and TNF-α seem to be stronger predictors for cognitive performance and decline than hs-CRP.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Neurology (clinical)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3