Identifying Aging and Alzheimer Disease–Associated Somatic Variations in Excitatory Neurons From the Human Frontal Cortex

Author:

Zhang Meng1,Bouland Gerard A.1,Holstege Henne1ORCID,Reinders Marcel J.T.1ORCID

Affiliation:

1. From the Delft Bioinformatics Lab (M.Z., G.A.B., H.H., M.J.T.R.), Delft University of Technology; Department of Human Genetics (M.Z., H.H.), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC; and Department of Human Genetics (G.A.B., M.J.T.R.), Leiden University Medical Center, the Netherlands.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics (clinical),Neurology (clinical)

Reference53 articles.

1. A genomic view of mosaicism and human disease;Biesecker LG;Nat Rev Genet.,2013

2. DNA damage, DNA repair, aging, and neurodegeneration;Maynard S;Cold Spring Harb Perspect Med.,2015

3. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease;Wang X;Biochim Biophys Acta.,2014

4. Somatic mutation, genomic variation, and neurological disease;Poduri A;Science.,2013

5. Insights into the role of somatic mosaicism in the brain;Paquola ACM;Curr Opin Syst Biol.,2017

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