Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials

Author:

Ferreira Pamela C.L.1,Ferrari-Souza João Pedro1ORCID,Tissot Cécile1ORCID,Bellaver Bruna1ORCID,Leffa Douglas T.1ORCID,Lussier Firoza1,Povala Guilherme1ORCID,Therriault Joseph1,Benedet Andréa L.1,Ashton Nicholas J.1ORCID,Cohen Ann D.1,Lopez Oscar L.1,Tudorascu Dana L.1,Klunk William E.1,Soucy Jean-Paul1,Gauthier Serge1,Villemagne Victor1,Zetterberg Henrik1ORCID,Blennow Kaj1ORCID,Rosa-Neto Pedro1ORCID,Zimmer Eduardo R.1ORCID,Karikari Thomas K.1ORCID,Pascoal Tharick A.1,

Affiliation:

1. From the Departments of Psychiatry (P.C.L.F., J.P.F.-S., C.T., B.B., D.T.L., F.L., G.P., A.D.C., D.L.T., W.E.K., V.V., T.K.K., T.A.P.) and Neurology (O.L.L.), School of Medicine, University of Pittsburgh, PA; Graduate Program in Biological Sciences: Biochemistry (J.P.F.-S., B.B., E.R.Z.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Translational Neuroimaging Laboratory (C.T., F.L., J.T., J.-P.S., P.R.-N.), McGill University Research Centre for Studies in Aging, Alzheimer's...

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Neurology (clinical)

Reference15 articles.

1. Alzheimer's disease drug development pipeline: 2021;Cummings J;Alzheimers Dement (NY),2021

2. NIA-AA research framework: toward a biological definition of Alzheimer's disease;Jack CR;Alzheimers Dement,2018

3. Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria;Dubois B;Alzheimers Dement,2016

4. Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

5. Two randomized phase 3 studies of aducanumab in early Alzheimer's disease;Budd Haeberlein S;J Prev Alzheimers Dis,2022

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