Author:
Durif F.,Vidailhet M.,Assal F.,Roche C.,Bonnet A. M.,Agid Y.
Abstract
Article abstract-The severity of parkinsonian motor disability and dyskinesias was evaluated in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist apomorphine, before and after low-dose clozapine (50 mg) for 18 +/- 2 days. There was a significant 59% improvement (p < 0.05) of apomorphine-induced dyskinesias without aggravation of parkinsonian motor disability following clozapine treatment. The results suggest that low-dose clozapine, already shown to improve psychotic symptoms, may help to reduce severe levodopa-induced dyskinesias in parkinsonian patients.NEUROLOGY 1997;48: 658-662
Publisher
Ovid Technologies (Wolters Kluwer Health)
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