Author:
Leppik I. E.,Boucher B. A.,Wilder B. J.,Murthy V. S.,Watridge C.,Graves N. M.,Rangel R. J.,Rask C. A.,Turlapaty P.
Abstract
ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phos-phatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
97 articles.
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