Author:
Chinnery P.F.,Taylor G.A.,Howell N.,Andrews R.M.,Morris C.M.,Taylor R.W.,McKeith I.G.,Perry R.H.,Edwardson J.A.,Turnbull D.M.
Abstract
Article abstract The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
95 articles.
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