Author:
Kandrotas Robert J.,Love James M.,Gal Peter,Oles Karen S.
Abstract
We report a patient with dialysis-induced encephalopathy who was taking divalproex sodium for a seizure disorder. Her serum valproic acid concentration appeared to be in the low therapeutic range at 54 mg/1 yet she continued to have seizure activity. The elimination half-life and apparent clearance of valproic acid were the same for both a dialysis and nondialysis day, indicating that hemodialysis/hemoperfusion has little effect on the overall removal of valmoic acid from the body.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
21 articles.
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