Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes

Author:

Boska M. D.,Welch K. M.A.,Barker P. B.,Nelson J. A.,Schultz L.

Abstract

Background: Previous single voxel 31P MRS pilot studies of migraine patients have suggested that disordered energy metabolism or Mg2+ deficiencies may be responsible for hyperexcitability of neuronal tissue in migraine patients. These studies were extended to include multiple brain regions and larger numbers of patients by multislice 31P MR spectroscopic imaging.Methods: Migraine with aura (MWA), migraine without aura (MwoA), and hemiplegic migraine patients were studied between attacks by 31P MRS imaging using a 3-T scanner.Results: Results were compared with those in healthy control subjects without headache. In MwoA, consistent increases in phosphodiester concentration [PDE] were measured in most brain regions, with a trend toward increase in [Mg2+] in posterior brain. In MWA, phosphocreatine concentration ([PCr]) was decreased to a minor degree in anterior brain regions and a trend toward decreased [Mg2+] was observed in posterior slice 1, but no consistent changes were found in phosphomonoester concentration [PME], [PDE], inorganic phosphate concentration ([Pi]), or pH. In hemiplegic migraine patients, [PCr] had a tendency to be lower, and [Mg2+] was significantly lower than in the posterior brain regions of control subjects. Trend analysis showed a significant decrease of brain [Mg2+] and [PDE] in posterior brain regions with increasing severity of neurologic symptoms.Conclusions: Overall, the results support no substantial or consistent abnormalities of energy metabolism, but it is hypothesized that disturbances in magnesium ion homeostasis may contribute to brain cortex hyperexcitability and the pathogenesis of migraine syndromes associated with neurologic symptoms. In contrast, migraine patients without a neurologic aura may exhibit compensatory changes in [Mg2+] and membrane phospholipids that counteract cortical excitability.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Neurology (clinical)

Reference18 articles.

1. The Concept of Migraine as a State of Central Neuronal Hyperexcitability

2. Brain excitability in migraine: evidence from transcranial magnetic stimulation studies

3. Magnesium and pH imaging of the human brain at 3.0 Tesla

4. Press WH, Teukolsky SA, Vetterling WT, Flannery BP. Numerical recipes in C, the art of scientific computing, 2nd ed. Cambridge: Cambridge University Press, 1992: 681.

5. Barker PB, Sibisi S. Nonlinear least squares analysis of in vivo 31P NMR data. In: Proceedings of the Society of Magnetic Resonance in Medicine, 9th Annual Meeting, August 18–20, 1990. New York, NY, Berkeley, CA: Society of Magnetic Resonance in Medicine, 1990;1089–1089. Abstract.

Cited by 82 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3