Posterior Cerebral Calcifications in Celiac Disease: Improvement with Gluten-free Diet
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Published:2020-12-03
Issue:
Volume:
Page:10.1212/CPJ.0000000000001021
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ISSN:2163-0402
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Container-title:Neurology: Clinical Practice
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language:en
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Short-container-title:Neurol Clin Pract
Author:
Alice Ray,Augustin Lecler,Catherine Vignal,Francois Simon Jean,Nina Di Donato,Romain Deschamps
Abstract
A 61-year-old man presented with a 15 years history of progressive bilateral vision loss. He reported neither gastrointestinal symptoms nor epilepsy. Brain CT and MRI showed bilateral occipital and cerebellar calcifications, and diffuse posterior white matter abnormalities (figure 1). EEG demonstrated no epileptiform abnormalities. Duodenal biopsy results confirmed celiac disease (CD) diagnosis. White matter abnormalities decreased substantially after 8 months of gluten-free diet, and vision loss progression stopped (figure 2). CD must be suspected in case of isolated neuro-visual disturbances with posterior cerebral calcifications, considering that gluten-free diet can halt the deterioration. (1, 2) Late onset is not rare considering that in adults, CD is characterized by non-bowel involvement and extraintestinal symptoms.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Neurology (clinical)